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Page 1
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain.
González Ibanez F, Picard K, Bordeleau M, Sharma K, Bisht K, Tremblay MÈ. González Ibanez F, et al. J Vis Exp. 2019 Oct 27;(152). doi: 10.3791/60510. J Vis Exp. 2019. PMID: 31710033
., trauma, infection, disease, or injury), microglial density, distribution, and morphology are altered in various manners, depending on the insult. Additionally, the described double-staining method allows visualization of infiltrating macrophages in the brain based on th …
., trauma, infection, disease, or injury), microglial density, distribution, and morphology are altered in various manners, depending on the …
Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.
Jamerson K, Weber MA, Bakris GL, Dahlöf B, Pitt B, Shi V, Hester A, Gupte J, Gatlin M, Velazquez EJ; ACCOMPLISH Trial Investigators. Jamerson K, et al. N Engl J Med. 2008 Dec 4;359(23):2417-28. doi: 10.1056/NEJMoa0806182. N Engl J Med. 2008. PMID: 19052124 Free article. Clinical Trial.
We hypothesized that treatment with the combination of an angiotensin-converting-enzyme (ACE) inhibitor and a dihydropyridine calcium-channel blocker would be more effective in reducing the rate of cardiovascular events than treatment with an ACE inhibitor plus a thiazide diureti …
We hypothesized that treatment with the combination of an angiotensin-converting-enzyme (ACE) inhibitor and a dihydropyridine calcium-channe …
Double robust estimation of optimal partially adaptive treatment strategies: An application to breast cancer treatment using hormonal therapy.
Talbot D, Moodie EEM, Diorio C. Talbot D, et al. Stat Med. 2023 Jan 30;42(2):178-192. doi: 10.1002/sim.9608. Epub 2022 Nov 21. Stat Med. 2023. PMID: 36408723
G-estimation and dynamic weighted ordinary least squares are double robust methods to identify optimal adaptive treatment strategies. ...Building on G-estimation and dWOLS, we propose estimators of such partially adaptive strategies and demonstrate their double robu …
G-estimation and dynamic weighted ordinary least squares are double robust methods to identify optimal adaptive treatment strategies. …
Double-Stranded Biotinylated Donor Enhances Homology-Directed Repair in Combination with Cas9 Monoavidin in Mammalian Cells.
Roche PJR, Gytz H, Hussain F, Cameron CJF, Paquette D, Blanchette M, Dostie J, Nagar B, Akavia UD. Roche PJR, et al. CRISPR J. 2018 Dec;1:414-430. doi: 10.1089/crispr.2018.0045. CRISPR J. 2018. PMID: 31021244
Homology-directed repair (HDR) induced by site specific DNA double-strand breaks with CRISPR-Cas9 is a precision gene editing approach that occurs at low frequency in comparison to indel forming non-homologous end joining (NHEJ). ...
Homology-directed repair (HDR) induced by site specific DNA double-strand breaks with CRISPR-Cas9 is a precision gene editing approac …
The inflammatory response, a mixed blessing for muscle homeostasis and plasticity.
Bouredji Z, Argaw A, Frenette J. Bouredji Z, et al. Front Physiol. 2022 Nov 23;13:1032450. doi: 10.3389/fphys.2022.1032450. eCollection 2022. Front Physiol. 2022. PMID: 36505042 Free PMC article. Review.
We also summarize current perspectives suggesting that the inflammatory process in muscle homeostasis and repair is a double-edged sword. Lastly, we review recent therapeutic approaches for treating muscle wasting disorders, with a focus on the RANK/RANKL/OPG pathway and i …
We also summarize current perspectives suggesting that the inflammatory process in muscle homeostasis and repair is a double-edged sw …
Near-infrared toroidal dipole response supported by silicon metasurfaces.
Li S, Li S, Wang Y. Li S, et al. Appl Opt. 2022 Sep 1;61(25):7388-7392. doi: 10.1364/AO.465264. Appl Opt. 2022. PMID: 36256039
The dielectric metasurfaces supporting non-radiative toroidal dipole resonances play important roles in nanophotonics. In this paper, toroidal dipole resonances using a double-axe nanostructure array in the near-infrared region are theoretically investigated by the …
The dielectric metasurfaces supporting non-radiative toroidal dipole resonances play important roles in nanophotonics. In this paper, toroid …
Double Exposure to Adverse Psychosocial Work Factors and High Family Responsibilities as Related to Ambulatory Blood Pressure at Work: A 5-Year Prospective Study in Women With White-Collar Jobs.
Gilbert-Ouimet M, Brisson C, Milot A, Vézina M. Gilbert-Ouimet M, et al. Psychosom Med. 2017 Jun;79(5):593-602. doi: 10.1097/PSY.0000000000000450. Psychosom Med. 2017. PMID: 28098718
No adverse effect on BP was observed for the double exposure to the psychosocial work factors of the demand-control model and high family responsibilities. ...BP elevations related to this double exposure may persist for several years....
No adverse effect on BP was observed for the double exposure to the psychosocial work factors of the demand-control model and high fa …
Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk.
Carrier M, Šimončičová E, St-Pierre MK, McKee C, Tremblay MÈ. Carrier M, et al. Front Mol Neurosci. 2021 Nov 4;14:749737. doi: 10.3389/fnmol.2021.749737. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34803607 Free PMC article. Review.
Although they represent up to 10% of all brain cells, we are only beginning to understand how much brain homeostasis relies on their physiological functions. Often compared to a double-edged sword, microglia hold the potential to exert neuroprotective roles that can also e …
Although they represent up to 10% of all brain cells, we are only beginning to understand how much brain homeostasis relies on their physiol …
Double jeopardy: two episodes of forearm compartment syndrome in the same patient.
Seth R, Vijayan R, Khandwala A. Seth R, et al. BMJ Case Rep. 2015 Jan 5;2015:bcr2014208079. doi: 10.1136/bcr-2014-208079. BMJ Case Rep. 2015. PMID: 25564596 Free PMC article.
A 55-year-old woman taking warfarin for previous deep venous thrombosis (DVT), presented with an acutely swollen and painful forearm after forcefully contracting her forearm flexor compartment while using a car hand brake and later, an axe. Compartment syndrome was diagnos …
A 55-year-old woman taking warfarin for previous deep venous thrombosis (DVT), presented with an acutely swollen and painful forearm after f …
Effect of topiramate on eating behaviours in Prader-Willi syndrome: TOPRADER double-blind randomised placebo-controlled study.
Consoli A, Çabal Berthoumieu S, Raffin M, Thuilleaux D, Poitou C, Coupaye M, Pinto G, Lebbah S, Zahr N, Tauber M, Cohen D, Bonnot O. Consoli A, et al. Transl Psychiatry. 2019 Nov 4;9(1):274. doi: 10.1038/s41398-019-0597-0. Transl Psychiatry. 2019. PMID: 31685813 Free PMC article. Clinical Trial.
Prader-Willi Syndrome (PWS) is a rare genetic syndrome leading to severe behavioural disorders and mild cognitive impairment. The objective of this double-blind randomised placebo-controlled trial was to study the efficacy and tolerance of topiramate on behavioural disorde …
Prader-Willi Syndrome (PWS) is a rare genetic syndrome leading to severe behavioural disorders and mild cognitive impairment. The objective …
49 results